1; Calculate the dose of ALIMTA and determine the number of vials needed
Premedication almost always includes dexamethasone, which can be associated with multiple adverse effects if taken for We report 14 cases of metastatic non-small-cell-lung-cancer patients who were premedicated with a single dose of dexamethasone 20 mg prior to pemetrexed or pemetrexed-based chemotherapy
(5
Special pediatric considerations are noted when applicable, otherwise adult provisions
• Premedication regimen: Instruct patients to take folic acid and vitamin B 12 Pretreatment with dexamethasone or equivalent reduces cutaneous reaction
Alimta is used to treat non-small cell lung cancer and mesothelioma, a form of lung cancer associated with exposure to asbestos
4) • Administer dexamethasone 4 mg orally, twice daily the day
Pretreatment with dexamethasone or
1) • Bone marrow suppression: Reduce doses for subsequent cycles based on hematologic and nonhematologic toxicities
(5
Among the 70 patients included, 39 received the alternative regimen prior to a total of 114 chemotherapy cycles, while the other 31 patients received the usual
) Vitamin Supplementation paclitaxel, studies of premedication for docetaxel dem-onstrated that premedication with dexamethasone, cimetidine, and diphenhydramine beginning the day before chemotherapy reduced the incidence of HSRs to about 13%
It affects enzymes within cancer cells to kill cancer cells or prevent them growing and multiplying
Patients must take Recommended Dosage Modifications for Adverse Reactions: Myelosuppressive toxicity: ANC less than 500 cells/mm3 AND platelets at least 50,000 cells/mm3 OR platelet count less than 50,000 cells/mm3 without bleeding: Dose for next cycle should be 75% of previous dose
19
Pemetrexed, sold under the brand name Alimta among others, is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer (NSCLC)
o Your healthcare provider will give you vitamin B12 injections during treatment with ALIMTA
Carboplatin, Pemetrexed and Pembrolizumab (except for the standard dexamethasone required with pemetrexed) because of their potential interference with the pharmacodynamic activity and efficacy of • Premedication regimen: Prior to treatment with ALIMTA, initiate supplementation with oral folic acid and intramuscular vitamin B
Patient information: pemetrexed premedication updated to align with clinical information; Version number changed to V
ALIMTA 100 mg, poudre pour solution à diluer pour perfusion B/1 (CIP : 34009 383 080 2 0) ALIMTA 500 mg, poudre pour solution à diluer pour perfusion B/1 (CIP : 34009 565 825 3 2) Laboratoire LILLY Code ATC L01BA04 (analogues de l’acide folique) Motif de l’examen ALIMTA and continue until 21 days after the last dose of ALIMTA